Tag: Antagonist

For research use only. We do not sell to patients. MK-3207 Hydrochloride CAS No. : 957116-20-0 Biological Activity：MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3. Research Area：Neurological Disease Targets：CGRP Receptor Related […]

For research use only. We do not sell to patients. Broflanilide CAS No. : 1207727-04-5 Biological Activity：Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM. Research Area：Neurological Disease Targets：GABA Receptor […]

For research use only. We do not sell to patients. Fluxametamide CAS No. : 928783-29-3 Biological Activity：Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls. Research Area：Others Targets：GABA Receptor Related Screening Libraries:Bioactive Compound […]

For research use only. We do not sell to patients. Afimetoran CAS No. : 2171019-55-7 Biological Activity：Afimetoran is a toll-like receptor antagonist, which can be used in the research of inflammatory and autoimmune diseases. Research Area：Inflammation/Immunology Targets：Toll-like Receptor (TLR) Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Clinical Compound […]

For research use only. We do not sell to patients. cis-(Z)-Flupentixol dihydrochloride CAS No. : 51529-01-2 Biological Activity：cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively[2]. Research Area：Neurological Disease Targets：Dopamine Receptor|5-HT Receptor Related Small Molecules:F 13714;Alizapride hydrochloride;Thioproperazine;Mosapride-d5;Bromopride-d3;Nuciferine;Glaucine;Renzapride;SB-277011 dihydrochloride;LY […]

For research use only. We do not sell to patients. TRPM8 antagonist 3 CAS No. : 2102179-29-1 Biological Activity：TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM. Research Area：Others Targets：TRP Channel Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Mechanoreceptors Compound Library; Related Small Molecules:V116517;GSK2332255B;Pregnenolone […]

For research use only. We do not sell to patients. Enclomiphene citrate CAS No. : 7599-79-3 Biological Activity：Enclomiphene ((E)-Clomiphene) citrate is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene citrate can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes. Research Area：Endocrinology|Metabolic Disease […]

For research use only. We do not sell to patients. TCS-OX2-29 CAS No. : 372523-75-6 Biological Activity：TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1[2]. Research Area：Cancer|Endocrinology Targets：Orexin Receptor (OX Receptor) […]

For research use only. We do not sell to patients. PD176252 CAS No. : 204067-01-6 Biological Activity：PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, […]

For research use only. We do not sell to patients. Fanapanel CAS No. : 161605-73-8 Biological Activity：Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. Research Area：Neurological Disease Targets：iGluR Related Screening Libraries:Clinical Compound Library […]