Tag: Antagonist

For research use only. We do not sell to patients. Fz7-21 CAS No. : 2247635-23-8 Biological Activity：Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM […]

For research use only. We do not sell to patients. TR antagonist 1 CAS No. : 500794-88-7 Biological Activity：TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively. Research Area：Metabolic Disease|Endocrinology Targets：Thyroid Hormone Receptor Related Screening Libraries:Bioactive Compound Library Plus;Endocrinology Compound Library;Targeted […]

For research use only. We do not sell to patients. Orphenadrine hydrochloride CAS No. : 341-69-5 Biological Activity：Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride […]

For research use only. We do not sell to patients. LY393558 CAS No. : 271780-64-4 Biological Activity：LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of 5-HT1B and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression. […]

For research use only. We do not sell to patients. MSG606 TFA Biological Activity：MSG606 TFA is a potent human MC1 receptor antagonist (IC50=17 nM). MSG606 TFA also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). MSG606 TFA exhibits binding affinity for A375 melanoma cells in vitro. MSG606 […]

For research use only. We do not sell to patients. GSK1521498 free base CAS No. : 1007573-18-3 Biological Activity：GSK1521498 free base is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base has the potential for disorders of compulsive consumption of food, alcohol, and drugs. Research Area：Neurological Disease Targets：Opioid Receptor Related Small Molecules:ORL1 antagonist […]

For research use only. We do not sell to patients. LY367385 hydrochloride CAS No. : 2829282-00-8 Biological Activity：LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic […]

For research use only. We do not sell to patients. PF-06291874 CAS No. : 1393124-08-7 Biological Activity：PF-06291874 is a highly potent, non-peptide and orally active glucagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM)[2]. Research Area：Metabolic Disease Targets：GCGR Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. Flavoxate-d4 hydrochloride CAS No. : 1189678-43-0 Biological Activity：Flavoxate-d4 hydrochloride (Rec-7-0040-d4) is the deuterium labeled Flavoxate hydrochloride. Flavoxate Hydrochloride is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic[2]. Research Area：Neurological Disease Targets：mAChR Related Small Molecules:VU0357017 hydrochloride;TBPB;Imidafenacin;Sabcomeline;MK-6884;Brompheniramine-d6 maleate;Navafenterol saccharinate;DREADD agonist 21;Cyclobuxine D;Brompheniramine […]

For research use only. We do not sell to patients. Cetirizine CAS No. : 83881-51-0 Biological Activity：Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[2][3]. Research Area：Inflammation/Immunology|Endocrinology Targets：Histamine Receptor Related Small Molecules:Tripelennamine;Brompheniramine-d6 […]