Tag: Activator|Inhibitor

For research use only. We do not sell to patients. Targapremir-210 CAS No. : 1049722-30-6 Biological Activity：Targapremir-210 (TGP-210) is a potent and selective miR-210 (miRNA-210, microRNA-210) inhibitor. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (Kd~200 nM). Research Area：Cancer Targets：MicroRNA|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Anti-Cancer Compound Library;Anti-Breast Cancer Compound Library; […]

For research use only. We do not sell to patients. Roxadustat-d5 CAS No. : 2043026-13-5 Biological Activity：Roxadustat-d5 is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin. Research Area：Cancer Targets：Ferroptosis|HIF/HIF Prolyl-Hydroxylase Related Small Molecules:CIL56;DB0614;TC-S 7009;Ciclopirox-d11;Ciclopirox olamine;Curcumin;Glucosamine-13C hydrochloride;HIF1-IN-3;Prolyl Hydroxylase inhibitor […]

For research use only. We do not sell to patients. ζ-Stat CAS No. : 3316-02-7 Biological Activity：ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[2]. Research Area：Cancer Targets：PKC|Apoptosis Related Screening Libraries:Bioactive Compound Library […]

For research use only. We do not sell to patients. GW 5074 CAS No. : 220904-83-6 Biological Activity：GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms[2]. Research Area：Cancer Targets：Raf|Apoptosis Related Screening Libraries:Natural […]

For research use only. We do not sell to patients. 2-Aminoethyl diphenylborinate-d10 Biological Activity：2-Aminoethyl diphenylborinate-d10 (2-APB-d10) is the deuterium labeled 2-Aminoethyl diphenylborinate. 2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3)[2][3]. Research Area：Others Targets：Calcium Channel|TRP Channel Related […]

For research use only. We do not sell to patients. Arteannuin B CAS No. : 50906-56-4 Biological Activity：Arteannuin B co-occurs with artemisinin, which is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae). Arteannuin B shows anti-SARS-CoV-2 potential with an EC50 of 10.28 μM[2]. Research Area：Infection Targets：Ferroptosis|SARS-CoV Related Screening Libraries:Covalent Screening Library […]

For research use only. We do not sell to patients. AEE788 CAS No. : 497839-62-0 Biological Activity：AEE788 is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively. Research Area：Cancer Targets：EGFR|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound […]

For research use only. We do not sell to patients. Sirtinol CAS No. : 410536-97-9 Biological Activity：Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively[2][3][4]. Research Area：Cancer Targets：Autophagy|Sirtuin|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Histone […]

For research use only. We do not sell to patients. Nevanimibe CAS No. : 133825-80-6 Biological Activity：Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical […]

For research use only. We do not sell to patients. Luminespib CAS No. : 747412-49-3 Biological Activity：Luminespib (VER-52296) is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively. Research Area：Cancer Targets：Autophagy|HSP|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage […]