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Product Name : MidkineTarget points: CellmidStatus: MidkineOrganization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips […]

The Nobel Prize in Physiology or Medicine 2024 Discovery of micrornas and their role in post-transcriptional gene regulation On October 7, the Karolinska Institute in Sweden announced that the 2024 Nobel Prize in Physiology or Medicine will be awarded to American scientists Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) and its […]

With the increasing trend of global aging, sarcopenia has become a significant public health issue. Sarcopenia, a loss of skeletal muscle mass and function associated with aging, is a progressive and widespread skeletal muscle disease. Goji berry, also known as “Gou qi zi” in China, is a traditional Chinese herb that can enhance the structure […]

Mitochondrial biogenesis Mitochondrial quality control (MQC) is a comprehensive network that monitors mitochondrial quality and serves as an endogenous protective program, which is crucial for maintaining mitochondrial homeostasis and function[1]. MQC coordinates various processes, such as biogenesis, mitochondrial fission, fusion, mitochondrial protein degradation, and mitophagy, to collectively regulate and maintain mitochondrial homeostasis[2]. Typically, after a […]

Autophagy Autophagy is a fundamental process that degrades various components within the cell. Autophagy can be non-selective, where cytoplasmic materials are sequestered into autophagosomes for engulfment, typically occurring during nutrient deprivation. In contrast, selective autophagy degrades specific targets, such as damaged organelles: mitophagy, lysophagy, and ER-phagy, playing a crucial role in cellular quality control (Fig. […]

1. The Science Behind [16+8]: Intermittent Fasting First, the conclusion: It is feasible! The 16+8 weight loss method involves eating all three meals within an 8-hour window, followed by 16 hours of only water consumption, with no food intake. As early as 2022, Humaira Jamshed and colleagues published a randomized clinical trial in JAMA Internal […]

Description Kanamycins sulfate is a broad-spectrum antibiotic, can be used in certain severe staphylococcal or Gram-negative bacillary infections. Kanamycin sulfate has certain ototoxicity[1][2]. Molecular Weight：582.58 Formula：C18H38N4O15S CAS No.：70560–51–9 Appearance：Solid Color：White to off-white SMILES：[Kanamycins (sulfate)] Shipping：Room temperature in continental US; may vary elsewhere. Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month […]

Description：Clazosentan (Ro 61–1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5]. In Vitro：Clazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries[3]. Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for […]

Product Name : ZYZ-488Description:ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3.CAS: 1470302-79-4Molecular Weight:487.46Formula: C20H29N3O11Chemical Name: (2S, 3S, 4S, 5R, 6S)-6-4-[(4-carbamimidamidobutoxy)carbonyl]-2, 6-dimethoxyphenoxy-3, 4, 5-trihydroxyoxane-2-carboxylic acidSmiles : COC1=CC(=CC(OC)=C1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(=O)OCCCCNC(N)=NInChiKey: PVTAIJDQJJZCJP-WXZWTWHISA-NInChi : InChI=1S/C20H29N3O11/c1-30-10-7-9(18(29)32-6-4-3-5-23-20(21)22)8-11(31-2)15(10)33-19-14(26)12(24)13(25)16(34-19)17(27)28/h7-8,12-14,16,19,24-26H,3-6H2,1-2H3,(H,27,28)(H4,21,22,23)/t12-,13-,14+,16-,19+/m0/s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as […]

Product Name : PTX3 (human), (recombinant)Sequence: Purity: Molecular Weight:~42kDa. Due to glycosylation, PTX3 may migrate between 40-45kDa.Solubility : Appearance: Use/Stability : Description: CAS : Solubility: Formula: Additional Information : | Alternative Name Pentraxin 3, TSG14, TNF stimulated gene-14 | Application Notes ELISA and Western blot standard together with MAb to PTX3 ) and PAb to […]