Cuproptosis’s Knowledge Points!

Background of Cuproptosis 1.1 Copper homeostasis in tumor cells Copper is a cofactor for essential enzymes required by the human body and can maintain their homeostasis by acting across concentration gradients[1]. Normally, intracellular copper concentrations are kept at extremely low levels, and this is also true in cancer cells. The normal function of copper ions […]

Desmin/DES Protein, Human (His)

Description Desmin is a muscle-specific type III intermediate filament that is critical for muscle structural integrity. It forms myofibrils, interconnects Z-disks and strengthens muscle fibers. Desmin/DES Protein, Human (His) is the recombinant human-derived Desmin/DES protein, expressed by E. coli , with N-6*His labeled tag. The total length of Desmin/DES Protein, Human (His) is 210 a.a., with molecular […]

IL-2 Protein, Mouse

Description IL-2 Protein, Mouse is an immunomodulatory cytokine with widely varying functions including promotion of apoptosis, proliferation and survival of lymphocytes. Background Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For example, IL-2 facilitates cell death only in activated T cells when antigen and IL-2 are abundant. The […]

IGF-I/IGF-1 Protein, Human (70a.a)

Description IGF-I/IGF-1 Protein, Human (70a.a) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone; IGF-I/IGF-1 Protein also mediates neuroprotective mechanism. Background Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such […]