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Danoprevir

CAS No. : 850876-88-9

Biological Activity：Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC₅₀ of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC₅₀ higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC₅₀s=0.2-0.4 nM) as well as 2b and 3a (IC₅₀s=1.6, 3.5 nM)^[2]. Danoprevir is also a SARS-CoV 3CL^pro inhibitor with an IC₅₀ of 0.05 μM^[3].

Research Area：Infection

Targets：HCV|HCV Protease|SARS-CoV

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Antiviral Compound Library;Drug Repurposing Compound Library;Macrocyclic Compound Library;Anti-COVID-19 Compound Library;NMPA-Approved Drug Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Hepatitis C Virus Compound Library;

Related Small Molecules:HCV-IN-30;NS5A-IN-1;HCV-IN-38;SARS-CoV-2-IN-33;GRL-0496;Sennidin A;HCV-IN-31;Radalbuvir;Grazoprevir potassium salt;FGI-106 tetrahydrochloride;SARS-CoV-2-IN-19;Molnupiravir;SARS-CoV-2 Mpro-IN-3;BMS-986144;Oenothein B;MM3122;Ketotifen fumarate;Triton X-45(n=4);SARS-CoV-2-IN-16

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