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OM-153
CAS No. : 2406278-81-5
Biological Activity：OM-153 is a potent and orally active tankyrase inhibitor with IC50s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based Wnt/β-catenin signaling reporter activity with an IC50 value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM[2].
Research Area：Cancer
Targets：PARP|Wnt
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Cytoskeleton Compound Library;Orally Active Compound Library;Neuroprotective Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Rucaparib monocamsylate;AZD-2461;Wnt/β-catenin agonist 1;Senaparib;Dehydrocorydaline;Rucaparib hydrochloride;Niraparib tosylate;ARUK3001185;G007-LK;PROTAC PARP1 degrader;UPF 1069;Gallocyanine chloride;Fz7-21;Foxy-5 TFA;DP-C-4;Wnt/β-catenin agonist 4;Δ5-Avenasterol-d4;JW74;IQ 1;Heparan Sulfate;PARP14 inhibitor H10;CEP-9722;E7449;ETC-159;PARP1-IN-11;PI-1840;5,7-Dihydroxychromone;PARP-1/2-IN-1
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