Year: 2025

Mitochondrial biogenesis Mitochondrial quality control (MQC) is a comprehensive network that monitors mitochondrial quality and serves as an endogenous protective program, which is crucial for maintaining mitochondrial homeostasis and function[1]. MQC coordinates various processes, such as biogenesis, mitochondrial fission, fusion, mitochondrial protein degradation, and mitophagy, to collectively regulate and maintain mitochondrial homeostasis[2]. Typically, after a […]

Autophagy Autophagy is a fundamental process that degrades various components within the cell. Autophagy can be non-selective, where cytoplasmic materials are sequestered into autophagosomes for engulfment, typically occurring during nutrient deprivation. In contrast, selective autophagy degrades specific targets, such as damaged organelles: mitophagy, lysophagy, and ER-phagy, playing a crucial role in cellular quality control (Fig. […]

1. The Science Behind [16+8]: Intermittent Fasting First, the conclusion: It is feasible! The 16+8 weight loss method involves eating all three meals within an 8-hour window, followed by 16 hours of only water consumption, with no food intake. As early as 2022, Humaira Jamshed and colleagues published a randomized clinical trial in JAMA Internal […]

Description Kanamycins sulfate is a broad-spectrum antibiotic, can be used in certain severe staphylococcal or Gram-negative bacillary infections. Kanamycin sulfate has certain ototoxicity[1][2]. Molecular Weight：582.58 Formula：C18H38N4O15S CAS No.：70560–51–9 Appearance：Solid Color：White to off-white SMILES：[Kanamycins (sulfate)] Shipping：Room temperature in continental US; may vary elsewhere. Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month […]

Description：Clazosentan (Ro 61–1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5]. In Vitro：Clazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries[3]. Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for […]