March, 2025 - epigenetics modulation frontier

Nemonoxacin

Posted on March 20, 2025March 20, 2025 by haoyuan2014

Description：Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3]. IC50 & Target：Bacterial[1][2][3]. In Vitro：Nemonoxacin (0–5.51 µM; 24 h) shows good antibacterial activity in vitro[1]. MedChemExpress (MCE) has not independently confirmed the […]

GJ103 and Lamin B1 Antibody: How to Conduct Chronic Kidney Disease Research?

Posted on March 19, 2025March 19, 2025 by haoyuan2014

Chronic kidney disease (CKD) poses a significant global health issue, leading to the progressive loss of kidney function. Renal fibrosis commonly accompanies CKD, characterized by excessive deposition of extracellular matrix (ECM). This process causes tissue remodeling and scarring in the renal parenchyma. Myofibroblasts drive renal fibrosis through their proliferation and activation. 1. Role of Meis1 in CKD […]

GMP Small Molecules Empower Cell Therapy: Reshaping the Future of Medicine

Posted on March 19, 2025March 19, 2025 by haoyuan2014

In early January 2025, MIT Tech Review unveiled its annual list of top 10 breakthrough technologies poised to redefine the future. Among these, stem cell therapy stood out for its potential to treat diverse diseases—including neurodegenerative disorders, diabetes, cancer, and heart failure. This groundbreaking approach uses stem cells to replace damaged cells, offering hope for […]

AI Deep Learning Accelerates Drug Development

Posted on March 18, 2025March 18, 2025 by haoyuan2014

Deep learning is a subset of artificial intelligence (AI) that mimics the neural networks of the human brain to learn from large amounts of data, enabling machines to solve complex problems. Deep learning technology has made significant progress in the biomedical field. Researchers have developed a series of application based on deep learning for disease […]

ZYZ-488

Posted on March 18, 2025 by haoyuan2014

Product Name : ZYZ-488Description:ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3.CAS: 1470302-79-4Molecular Weight:487.46Formula: C20H29N3O11Chemical Name: (2S, 3S, 4S, 5R, 6S)-6-4-[(4-carbamimidamidobutoxy)carbonyl]-2, 6-dimethoxyphenoxy-3, 4, 5-trihydroxyoxane-2-carboxylic acidSmiles : COC1=CC(=CC(OC)=C1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(=O)OCCCCNC(N)=NInChiKey: PVTAIJDQJJZCJP-WXZWTWHISA-NInChi : InChI=1S/C20H29N3O11/c1-30-10-7-9(18(29)32-6-4-3-5-23-20(21)22)8-11(31-2)15(10)33-19-14(26)12(24)13(25)16(34-19)17(27)28/h7-8,12-14,16,19,24-26H,3-6H2,1-2H3,(H,27,28)(H4,21,22,23)/t12-,13-,14+,16-,19+/m0/s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as […]

PTX3 (human), (recombinant)

Posted on March 17, 2025 by haoyuan2014

Product Name : PTX3 (human), (recombinant)Sequence: Purity: Molecular Weight:~42kDa. Due to glycosylation, PTX3 may migrate between 40-45kDa.Solubility : Appearance: Use/Stability : Description: CAS : Solubility: Formula: Additional Information : | Alternative Name Pentraxin 3, TSG14, TNF stimulated gene-14 | Application Notes ELISA and Western blot standard together with MAb to PTX3 ) and PAb to […]

Ginsenoside Rh2

Posted on March 17, 2025 by haoyuan2014

Product Name : Ginsenoside Rh2Description:Ginsenoside Rh2 is isolated from the root of Ginseng. Ginsenoside Rh2 induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.CAS: 78214-33-2Molecular Weight:622.87Formula: C36H62O8Chemical Name: (2R, 3R, 4S, 5S, 6R)-2-{[(1S, 3aR, 3bR, 5aR, 7S, 9aR, 9bR, 11R, 11aR)-11-hydroxy-1-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-3a, 3b, 6, 6, 9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-6-(hydroxymethyl)oxane-3, 4, 5-triolSmiles […]

PDK1 polyclonal antibody

Posted on March 16, 2025 by haoyuan2014

Product Name : PDK1 polyclonal antibodySequence: Purity: Molecular Weight:Solubility : Appearance: Use/Stability : Description: PDK-1 (Pyruvate dehydrogenase kinase-1) is a 48 kDa protein kinase. It is a member of the mitrochondrial matrix protein kinase family and is related to the histidine protein kinases found in prokaryotes. PDK-1 is responsible for phosphorylation and concomitant inactivation of […]

Polyphyllin I

Posted on March 16, 2025 by haoyuan2014

Product Name : Polyphyllin IDescription:Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis.CAS: 50773-41-6Molecular Weight:855.02Formula: C44H70O16Chemical Name: (2S, 3R, 4R, 5R, 6S)-2-[(2R, 3R, 4S, […]

Meloxicam-d3

Posted on March 16, 2025 by haoyuan2014

Product Name : Meloxicam-d3Description:Meloxicam-d3 is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.CAS: 942047-63-4Molecular Weight:354.42Formula: C14H13N3O4S2Chemical Name: 4-hydroxy-2-(²H₃)methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2H-1λ⁶,2-benzothiazine-3-carboxamideSmiles : [2H]C([2H])([2H])N1C(=C(O)C2=CC=CC=C2S1(=O)=O)C(=O)NC1=NC=C(C)S1InChiKey: ZRVUJXDFFKFLMG-BMSJAHLVSA-NInChi : InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)/i2D3Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous […]