Product Name :
iFluor™ 488 Conjugated CD47 Mouse Monoclonal Antibody [1B1]
Predicted band size :
Observed band size :
Synonyms:
Antigen identified by monoclonal antibody 1D8 antibody Antigenic surface determinant protein OA3 antibody CD 47 antibody CD47 antibody CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody CD47 antigen antibody CD47 glycoprotein antibody CD47 molecule antibody CD47_HUMAN antibody IAP antibody 展开
Function :
CD47 is an integral membrane protein that plays a role in the regulation of cation fluxes across cell membranes. Specifically, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to the extracellular matrix. It is also a receptor for the C-terminal cell binding domain of thrombospondin (SIRP). Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. CD47 is absent from Rh-null erythrocytes, but does play a role in cell adhesion in non-erythroid cells and may prevent premature elimination of erythrocytes. It may also be involved in membrane permeability changes following viral infection. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. CD47 is expressed on hemopoietic cells, epithelial cells, endothelial cells and fibroblasts and is strongly expressed in brain and mesenchymal cells.Salmeterol
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein within human CD47 aa 19-141 (Extracellular).Obiltoxaximab
Species reactivity:
Human
Verify application:
FC
Coupling :
iFluor™ 488
Clone number:
1B1
RRID:
AB_3071720
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:24381199 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS
Subtype:
IgG1
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
35 kDa
Positive control :
MCF-7.