Product Name :
CD35 Mouse Monoclonal Antibody [A4F3]
Predicted band size :
224 kDa
Observed band size :
280 kDa
Synonyms:
C3 binding protein antibody C3b/C4b receptor antibody C3BR antibody C4BR antibody CD 35 antibody CD35 antibody CD35 antigen antibody complement component (3b/4b) receptor 1 (Knops blood group) antibody complement component (3b/4b) receptor 1 including Knops blood group system antibody Complement component receptor 1 antibody 展开
Function :
Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. This gene is a member of the regulators of complement activation (RCA) family and is located in the ‘cluster RCA’ region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Synthetic peptide within C-terminal human CD35.
Species reactivity:
Human
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
A4F3
RRID:
AB_3071746
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃.Astemizole Avoid repeated freeze / thaw cycles.Baclofen
Storage buffer solution:
PBS (pH7.PMID:23927631 4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG1
Purification method :
Protein G affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 224 kDa
Positive control :
TF-1 cell lysate, human kidney tissue lysate, human tonsil tissue, human Hodgkin lymphoma tissue, human small intestine tissue.