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SNIPER(ABL)-039

CAS No. : 2222354-29-0

Biological Activity：SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 nM. IC₅₀s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively.

Research Area：Cancer

Targets：Bcr-Abl|SNIPERs

Related Small Molecules:AT9283;Bafetinib;Pivanex;Flumatinib mesylate;IHMT-TRK-284;SNIPER(ABL)-049;Olverembatinib;GNF-2;CT-721;SNIPER(ABL)-015;GNF-5;BCR-ABL-IN-4;SNIPER(ABL)-033;CHMFL-ABL-039;BCR-ABL-IN-6;c-ABL-IN-2;SNIPER(ABL)-058;ON 146040;HG-7-85-01;PROTAC AR Degrader-4;SNIPER(ER)-87;CHMFL-ABL/KIT-155;Radotinib-d6;BCR-ABL-IN-1

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