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CAS No. : 1262036-50-9

Biological Activity:LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer’s disease treatment.

Research Area:Neurological Disease


Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Neuronal Signaling Compound Library;Clinical Compound Library;CNS-Penetrant Compound Library;Drug Repurposing Compound Library;Covalent Screening Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;

Related Small Molecules:BACE1-IN-9;β-Secretase Inhibitor II;Cassiaside;Glabrolide;OM99-2;JNJ-67569762;β-Secretase Inhibitor III;BACE1-IN-12;BACE1-IN-11;Multitarget AD inhibitor-1;BACE-1 inhibitor 1;BACE1-IN-8;AM-6494;LX2343;LY2811376;COX-2-IN-22;AZD3839 free base;Aloenin;β-Secretase Inhibitor IV;AChE/BChE/BACE-1-IN-2;BACE1-IN-4;Sophoflavescenol;Aloeresin D;BACE-IN-1;BACE-1 inhibitor 2;Epiberberine chloride;BACE1-IN-2

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