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GSK3494245
CAS No. : 2080410-41-7
Biological Activity：GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 µM; enriched THP-1 extracts IC50=40µM). GSK3494245 exhibits attractive biological and biosafety properties[2].
Research Area：Infection
Targets：Parasite|Proteasome
Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Metabolism/Protease Compound Library;Clinical Compound Library;Ubiquitination Compound Library;Orally Active Compound Library;Anti-Blood Cancer Compound Library;Antiparasitic Compound library;
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