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TRPC6-PAM-C20

CAS No. : 667427-75-0

Biological Activity：TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca²⁺ concentrations ([Ca²⁺]i) in TRPC6-expressing HEK293 cells with an EC₅₀ of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals.

Research Area：Neurological Disease

Targets：TRP Channel

Related Small Molecules:V116517;GSK2332255B;Pregnenolone monosulfate sodium;TRPC5-IN-4;OptoBI-1;SB-705498;TRPC3/6-IN-1;ABT-239;Pyr3;Asivatrep;Ononetin;TRPM8 antagonist 3;FEMA 4809;Hydroxy-α-sanshool;GsMTx4 TFA;TRPM4-IN-1;Palvanil;Pregnenolone monosulfate sodium-13C2,d2;Capsazepine;MSP-3;TRPM4-IN-2;Pregnenolone-d4-1;Umbellulone;Icilin;DS88790512;TRPV antagonist 1;ML-SA1

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