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Plecanatide acetate

CAS No. : 1075732-84-1

Biological Activity：Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC₅₀ of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis^[2]^[3].

Research Area：Inflammation/Immunology

Targets：Guanylate Cyclase

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;Bioactive Compound Library Plus;Peptide Library;

Related Small Molecules:Cinaciguat hydrochloride;Zagociguat;LY83583;Plecanatide;(4-Acetamidocyclohexyl) nitrate;N-Salicyloyltryptamine;Guanylin(human);Ebselen oxide;BAY 41-2272;MGV354;NS-2028;BI 703704;Dolcanatide;Prepro-ANF (56-92), human;Nelociguat;Indusatumab;CFM 1571 hydrochloride;Cenderitide;BAY 41-8543;Ataciguat;MM 419447;Guanylate cyclase-IN-1;Praliciguat

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