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LM11A-31 dihydrochloride
CAS No. : 1243259-19-9
Biological Activity:LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. M11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer’s disease mouse models with mid- to late-stage disease progression[2].
Research Area:Neurological Disease
Targets:Neurotensin Receptor
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;CNS-Penetrant Compound Library;Orally Active Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Targeted Diversity Library;
Related Small Molecules:NTRC-824;THX-B;JMV 449;ML314;SORT-PGRN interaction inhibitor 1;AF38469;Kinetensin;Contulakin G;SR 142948;[Lys8, Lys9]-Neurotensin (8-13);Neurotensin;SBI-553;AF40431;[D-Trp11]-Neurotensin;VGD071;Neurotensin(8-13)
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