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Indirubin-3′-oxime
CAS No. : 667463-82-3
Biological Activity：Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes[2][3].
Research Area：Neurological Disease
Targets：CDK|GSK-3|JNK
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Transcription Factor-Targeted Library;Glucose Metabolism Compound Library;Antidepressant Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Akt/NF-κB/JNK-IN-1;DB0614;TCS2002;JNK3 inhibitor-2;Dinaciclib;AR-A014418;SNS-032;CC-671;(E/Z)-Zotiraciclib;CDK1-IN-4;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;T025;Flavopiridol;CDK8-IN-3;CDK9-IN-12;FLT3/CDK4-IN-1;GFB-12811;GSK 3 Inhibitor IX;Eciruciclib;JIP-1(153-163) TFA;CDK-IN-6;Lerociclib dihydrochloride;CDK4/6-IN-13;ON-013100;(2S,3R)-Voruciclib hydrochloride;Cucurbitacin E;THZ1
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