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Imatinib
CAS No. : 152459-95-5
Biological Activity:Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively[2][3][4]. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV[5].
Research Area:Cancer
Targets:Autophagy|Bcr-Abl|c-Kit|PDGFR|SARS-CoV
Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Antiviral Compound Library;Autophagy Compound Library;Drug Repurposing Compound Library;Reprogramming Compound Library;NMPA-Approved Drug Library;Cytoskeleton Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Alzheimer’s Disease Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Targeted Therapy Drug Library ;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Rare Diseases Drug Library;Children’s Drug Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:AT9283;Bafetinib;Pivanex;Henatinib;SARS-CoV-2-IN-33;GRL-0496;SNIPER(ABL)-039;c-Kit-IN-5-1;Flumatinib mesylate;IHMT-TRK-284;Grazoprevir potassium salt;PDGFRα/FLT3-ITD-IN-2;SARS-CoV-2-IN-19;Molnupiravir;SARS-CoV-2 Mpro-IN-3;MM3122;Ketotifen fumarate;PP58;Chiauranib;SARS-CoV-2-IN-16;Zeteletinib
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