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hSMG-1 inhibitor 11j
CAS No. : 1402452-15-6
Biological Activity：hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.
Research Area：Cancer
Targets：mTOR|CDK|GSK-3|PI3K
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Antioxidant Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Glucose Metabolism Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:D-α-Hydroxyglutaric acid disodium;DB0614;TCS2002;Umbralisib hydrochloride;Dinaciclib;AR-A014418;SNS-032;Topoisomerase I/II inhibitor 3;CC-671;Cyclovirobuxine D;(E/Z)-Zotiraciclib;Rigosertib sodium;Tenalisib R Enantiomer;CDK1-IN-4;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;PI3kδ inhibitor 1;WYE-354;PI3K/VEGFR2-IN-1;T025;Flavopiridol;CDK8-IN-3;CDK9-IN-12;L-Leucine-1-13C,15N;FLT3/CDK4-IN-1;GFB-12811;GSK 3 Inhibitor IX
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