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GSK-J4 hydrochloride

CAS No. : 1797983-09-5

Biological Activity：GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK-J4 hydrochloride is a cell permeable prodrug of GSK-J1^[2]^[3].

Research Area：Cancer

Targets：Histone Demethylase

Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Anti-diabetic Compound Library;Anti-Cancer Metabolism Compound Library;Human Metabolite Library;Cancer Stem Cells Compound Library;

Related Small Molecules:Bomedemstat ditosylate;LSD1/ER-IN-1;PBIT;JQKD82;KDOAM-25 citrate;GSK-J1 lithium salt;S2116;LSD1-IN-16;TAK-418;NCGC00247743;DS17701585;KDM2B-IN-3;S2101;LSD1/2-IN-3;KDM5-IN-1;GSK467;S2157;PFI-90;FY-56;Eicosapentaenoic Acid;LSD1-IN-20;KDM5A-IN-1;Bizine;Procaine-d4 hydrochloride

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