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DS-1205b free base

CAS No. : 1855860-24-0

Biological Activity：DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC_{50_{of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC_{50_{s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo.}}}}

Research Area：Cancer

Targets：c-Met/HGFR|Trk Receptor|TAM Receptor

Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Kinase Inhibitor Library;Neuronal Signaling Compound Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Covalent Screening Library;Anti-Lung Cancer Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Cancer Stem Cells Compound Library;

Related Small Molecules:AMG-208;D6808;hTrkA-IN-1;MET kinase-IN-2;c-Met-IN-9;Tyrosine kinase-IN-4;IHMT-TRK-284;Axl-IN-5;PROTAC Axl Degrader 2;Savolitinib;ANA-12;UNC2250;Foretinib;PF-04217903 phenolsulfonate;Larotrectinib sulfate;N-Acetyl-5-hydroxytryptamine;MK-2461;R916562;LM22B-10;XL092;D5261;SAR125844;MK-8033 hydrochloride;N-Acetyl-5-hydroxytryptamine-d3;Axl-IN-3;Gilteritinib-d8;7,8-Dihydroxyflavone;TRK-IN-18;TRK-IN-12

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