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Diclofensine hydrochloride
CAS No. : 34041-84-4
Biological Activity：Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.
IC50 value:
Target: Dopamine reuptake inhibitor
The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE). The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake [2]. Diclofensine, in concentrations of 0.01, 0.1 and 1 microM caused a marked decrease of 3H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration (50 microM). On the other hand, diclofensine (50 microM) caused a 3 fold enhancement of K+-evoked DA release [3].
Research Area：Neurological Disease
Targets：Dopamine Transporter
Related Screening Libraries:Bioactive Compound Library Plus;Neuronal Signaling Compound Library;Human Metabolite Library;
Related Small Molecules:Diclofensine;13-Hydroxyisobakuchiol;Fipexide;Vanoxerine;SPD-473 citrate;Diclofensine-d3 hydrochloride;Pseudoisocyanine iodide;Bisacodyl;AHN 1-055 hydrochloride;BMS-466442;Tesofensine;Dasotraline hydrochloride;DOV-216,303 Free Base;GBR 12935;J-147;Centanafadine-d7 hydrochloride;Centanafadine hydrochloride
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