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AVN-944
CAS No. : 297730-17-7
Biological Activity：AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research[2][3].
Research Area：Cancer|Infection
Targets：Arenavirus|DNA/RNA Synthesis|Bcl-2 Family|Caspase|Apoptosis
Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Antiviral Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Covalent Screening Library;Pyroptosis Compound Library;Orally Active Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Targeted Diversity Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Ametantrone;ST-193 hydrochloride;BJE6-106;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;BI-3812;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5
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