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Avatrombopag

CAS No. : 570406-98-3

Biological Activity：Avatrombopag (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag mimics the biological activities of TPO. Avatrombopag increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A^[2][3].

Research Area：Inflammation/Immunology

Targets：Thrombopoietin Receptor

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Drug-Induced Liver Injury (DILI) Compound Library;Rare Diseases Drug Library;Children’s Drug Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:Avatrombopag-d8 hydrochloride;Rafutrombopag diolamine;Avatrombopag hydrochloride;Lusutrombopag-d13;Lusutrombopag;Rafutrombopag;Hetrombopag;TPO agonist 1

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