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CAS No. : 1586787-08-7

Biological Activity:CMF019 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin[2].

Research Area:Cardiovascular Disease

Targets:Apelin Receptor (APJ)

Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Anti-Cardiovascular Disease Compound Library;Lipid Metabolism Compound Library ;

Related Small Molecules:ML221;Apelin-13 TFA;ML233;[Pyr1]-Apelin-13;APJ receptor agonist 5;APJ receptor agonist 1;ELA-11(human) TFA;NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal);AM-8123;Elabela(19-32) TFA;MM 07;APJ receptor agonist 4;ELA-32(human) TFA;Azelaprag;ELA-21 (human);APJ receptor agonist 6;MM 54;NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal);Apelin agonist 1;APJ receptor agonist 3

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