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Midostaurin

CAS No. : 120685-11-2

Biological Activity：Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM^[2]. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects^[3].

Research Area：Cancer

Targets：VEGFR|PKC|NO Synthase|c-Kit|Apoptosis

Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;TGF-beta/Smad Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Covalent Screening Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Cytoskeleton Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Targeted Therapy Drug Library ;Neurodegenerative Disease-related Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Rare Diseases Drug Library;Anti-Colorectal Cancer Compound Library ;Children’s Drug Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:Carboxy-PTIO potassium;Physalin A;Bomedemstat ditosylate;(Z)-FeCP-oxindole;Enpp/Carbonic anhydrase-IN-1;[Ala107]MBP(104-118) TFA;GK563;Calpeptin;Lobetyolin;Valeriandoid F;BJE6-106;Dinaciclib;VEGFR-2-IN-24;Ecteinascidin 770;MDM2-p53-IN-15;Myelin Basic Protein;BMS-690514;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8

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