BI-9627 hydrochloride

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BI-9627 hydrochloride

CAS No. : 1422252-46-7

Biological Activity:BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

Research Area:Cardiovascular Disease

Targets:Na+/H+ Exchanger (NHE)

Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:Cariporide;FR183998 free base;Tenapanor;BI-9627;Eniporide hydrochloride;Rimeporide hydrochloride;Monensin sodium salt;NHE3-IN-1;EIPA hydrochloride;Zoniporide hydrochloride hydrate;NHE3-IN-2

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