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CAS No. : 2438124-79-7

Biological Activity:ALV1 potently induces degradation of both Ikaros and Helios without unexpected off-target activity. ALV1 binds CRBN with IC50 of 0.55 µM. ALV1 degrades cells stably expressing IKZF1Δ and IKZF2Δ GFP fusions with mCherry reporter with DC50s of 2.5 and 10.3 nM.

Research Area:Cancer

Targets:Ligands for E3 Ligase|Molecular Glues

Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Cancer Compound Library;Clinical Compound Library;Ubiquitination Compound Library;Transcription Factor-Targeted Library;E3 Ligase Ligand Library;

Related Small Molecules:(S,R,S)-AHPC TFA;CRBN modulator-1;NRX-252114;cIAP1 ligand 4;(S,R,S)-AHPC-Me;cIAP1 ligand 2;(R)-CR8 trihydrochloride;Avadomide;Voclosporin;NRX-252262;TMX-4100;E3 ligase Ligand 23;VH032;BC-1215;VH032-cyclopropane-F;Tasisulam;FPFT-2216;KB02-COOH

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