Tag: Inducer|Inhibitor|Activator

For research use only. We do not sell to patients. Olaparib-d8 Biological Activity：Olaparib D8 (AZD2281 D8) is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[2][3][4]. Research Area：Cancer Targets：PARP|Autophagy|Mitophagy Related Small […]

For research use only. We do not sell to patients. Polyphyllin I CAS No. : 50773-41-6 Biological Activity：Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest […]

For research use only. We do not sell to patients. Aspirin CAS No. : 50-78-2 Biological Activity：Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin […]

For research use only. We do not sell to patients. Aspirin-d4 CAS No. : 97781-16-3 Biological Activity：Aspirin-d4 (Acetylsalicylic Acid-d4) is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[2]. Research Area：Inflammation/Immunology|Cancer Targets：Autophagy|Mitophagy|Virus Protease|COX Related Small Molecules:Akt/NF-κB/JNK-IN-1;SRPIN340;ZIKV-IN-4;COX-2/5-LOX-IN-3;Curcumin;Aminothiazole;CYP2C9/CYP2C19-IN-1;Ampyrone;COX-2-IN-24;Melatonin-d3;Zaltoprofen-d7;L-Lysine;α-Vitamin E-d6;1-Hydroxy-ibuprofen;Asaraldehyde;(-)-Epicatechin;L-Lysine-13C6,15N2,d9 dihydrochloride;20(S)-Ginsenoside Rg3;Resveratrol;Ginsenoside Rd;4E2RCat;Nimesulide D5;COX-2/5-LOX-IN-1;Clioquinol;S-(+)-Marmesin;Tazofelone;ESI-09 Trending […]

For research use only. We do not sell to patients. Pitavastatin-d4 hemicalcium Biological Activity：Pitavastatin-d4 (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient […]

For research use only. We do not sell to patients. Salicylic acid-d6 CAS No. : 285979-87-5 Biological Activity：Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Research Area：Cancer|Inflammation/Immunology Targets：Autophagy|Mitophagy|Apoptosis|COX Related Small Molecules:Physalin A;Bomedemstat ditosylate;Akt/NF-κB/JNK-IN-1;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;COX-2/5-LOX-IN-3;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine […]

For research use only. We do not sell to patients. Mollugin CAS No. : 55481-88-4 Biological Activity：Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression […]

For research use only. We do not sell to patients. Sorafenib-d4 CAS No. : 1207560-07-3 Biological Activity：Sorafenib-d4 (Bay 43-9006-d4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively. Research Area：Cancer Targets：Ferroptosis|FLT3|Autophagy|Raf|VEGFR|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;(Z)-FeCP-oxindole;CIL56;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Avutometinib;Lobetyolin;BJE6-106;Dinaciclib;VEGFR-2-IN-24;Ecteinascidin 770;MDM2-p53-IN-15;BMS-690514;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II […]

For research use only. We do not sell to patients. Quercetin-d5 CAS No. : 263711-78-0 Biological Activity：Quercetin-d5 is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, […]

For research use only. We do not sell to patients. Pitavastatin Calcium CAS No. : 147526-32-7 Biological Activity：Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol […]