Tag: Agonist|Inhibitor

For research use only. We do not sell to patients. Vilazodone CAS No. : 163521-12-8 Biological Activity：Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders[2]. Research […]

For research use only. We do not sell to patients. Resiquimod-d5 CAS No. : 2252319-44-9 Biological Activity：Resiquimod-d5 (R848-d5) is deuterium labeled Resiquimod. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α[2]. Research Area：Infection|Inflammation/Immunology Targets：HCV|Toll-like Receptor (TLR) Related Small Molecules:C29;TMX-201;HCV-IN-30;HCV-IN-38;RS 09;ODN 20844;Sennidin A;TLR7/8-IN-1;TLR8 […]

For research use only. We do not sell to patients. MEDICA16 CAS No. : 87272-20-6 Biological Activity：MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120[2]. […]

For research use only. We do not sell to patients. 4-Acetamidobutanoic acid CAS No. : 3025-96-5 Biological Activity：4-Acetamidobutanoic acid (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities. Research Area：Others Targets：Bacterial|GABA Receptor|Endogenous Metabolite Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Membrane Transporter/Ion Channel Compound Library;Metabolism/Protease Compound Library;Neuronal Signaling Compound […]

For research use only. We do not sell to patients. BMS-986339 CAS No. : 2477873-64-4 Biological Activity：BMS-986339 is an orally active, potent FXR agonist. BMS-986339 forms H-bond with His298 and ASN287 residues. BMS-986339 can be used in the research of primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and nonalcoholic steatohepatitis (NASH), anti-fibrosis. Research Area：Metabolic […]

For research use only. We do not sell to patients. 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione CAS No. : 37413-91-5 Biological Activity：21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition […]

For research use only. We do not sell to patients. Dagrocorat hydrochloride CAS No. : 1044535-61-6 Biological Activity：Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human […]

For research use only. We do not sell to patients. STING agonist-1 CAS No. : 702662-50-8 Biological Activity：STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM. Research Area：Infection Targets：STING|Virus Protease Related Screening Libraries:Bioactive […]

For research use only. We do not sell to patients. Camphor CAS No. : 76-22-2 Biological Activity：Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities. Camphor is a TRPV3 agonist[2]. Research Area：Cancer|Infection|Inflammation/Immunology Targets：Influenza Virus|TRP Channel Related Screening Libraries:Natural […]

For research use only. We do not sell to patients. Amitriptyline-d3 hydrochloride CAS No. : 342611-00-1 Biological Activity：Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline […]