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Cuproptosis’s Knowledge Points!
Background of Cuproptosis 1.1 Copper homeostasis in tumor cells Copper is a cofactor for essential enzymes required by the human body and can maintain their homeostasis by acting across concentration gradients[1]. Normally, intracellular copper concentrations are kept at extremely low levels, and this is also true in cancer cells. The normal function of copper ions […]
Kanamycins sulfate
Description Kanamycins sulfate is a broad-spectrum antibiotic, can be used in certain severe staphylococcal or Gram-negative bacillary infections. Kanamycin sulfate has certain ototoxicity[1][2]. Molecular Weight：582.58 Formula：C18H38N4O15S CAS No.：70560–51–9 Appearance：Solid Color：White to off-white SMILES：[Kanamycins (sulfate)] Shipping：Room temperature in continental US; may vary elsewhere. Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month […]
Imiquimod-d6
For research use only. We do not sell to patients. Imiquimod-d6 Biological Activity：Imiquimod-d6 (R 837-d6) is the deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal […]
LY2886721
For research use only. We do not sell to patients. LY2886721 CAS No. : 1262036-50-9 Biological Activity：LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity […]
VU0357017 hydrochloride
For research use only. We do not sell to patients. VU0357017 hydrochloride CAS No. : 1135242-13-5 Biological Activity：VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the […]
Sulfadimethoxine-d6
For research use only. We do not sell to patients. Sulfadimethoxine-d6 CAS No. : 73068-02-7 Biological Activity：Sulfadimethoxine-d6 (Sulphadimethoxine-d6) is the deuterium labeled Sulfadimethoxine. Sulfadimethoxine is a sulfonamide antibiotic used to treat many infections. Research Area：Infection Targets：Bacterial|Antibiotic Related Small Molecules:Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;Monascorubrin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Leucomycin;Isouvaretin;Antibacterial agent 99;Vidarabine monohydrate;Nafcillin;Antitubercular agent-28;Ochromycinone;Staurosporine;Nucleocidin;(±)-Leucine-13C-1;Ciclopirox-d11;Ciclopirox olamine;Clotrimazole-d5;SQ109;(R)-Camptothecin-d5 Trending products：Recombinant Proteins | Bioactive […]
N-(Mal-PEG6)-N-bis(PEG7-TCO)
For research use only. We do not sell to patients. N-(Mal-PEG6)-N-bis(PEG7-TCO) CAS No. : 2093152-84-0 Biological Activity：N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Research Area：Cancer Targets：PROTAC Linkers Related Small Molecules:Propargyl-PEG2-CH2COOH;NHS ester-PEG10-COOH;Tos-PEG5-Boc;Bis-PEG6-NHS ester;Azide-PEG12-alcohol;Fmoc-PEG6-NHS ester;Boc-C1-PEG3-C4-OBn;Boc-NH-PEG8-C2-Br;Propargyl-PEG14-Boc;m-PEG21-OH;Bromo-PEG3-THP;m-PEG8-Ms;Bis-PEG10-NHS ester;TCO-PEG3-acid;m-PEG8-DBCO;Azide-PEG6-Tos;Acid-PEG3-C2-Boc;m-PEG-mal (MW 2000);Benzyl-PEG7-t-butyl ester;Boc-Pip-alkyne-Ph-COOH;Biotin-PEG2-C6-azide;Bis-PEG4-acid;Active-mono-sulfone-PEG8-acid;Br-PEG6-C2-NHBoc;HO-PEG8-CH2COOH;NH2-PEG4-CH2CH2COOH;N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester;Bromoacetamido-PEG8-Boc;Carboxy-PEG2-sulfonic acid Trending products：Recombinant Proteins | Bioactive Screening Libraries | […]
Carboxy-PTIO potassium
For research use only. We do not sell to patients. Carboxy-PTIO potassium CAS No. : 148819-94-7 Biological Activity：Carboxy-PTIO potassium is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model[2][3]. […]