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Rottlerin
CAS No. : 82-08-6
Biological Activity：Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation[2][3]. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection[4][5].
Research Area：Infection|Cancer
Targets：Autophagy|PKC|HIV|Apoptosis
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