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Necrostatin 2 S enantiomer

CAS No. : 852391-20-9

Biological Activity：Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2. Necrostatin 2 is a potent necroptosis inhibitor, acts as a RIPK1 inhibitor lacking the IDO-targeting effect.
Target: RIPK1 [4]
Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers.
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).

Research Area：Cancer

Targets：RIP kinase

Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;NF-κB Signaling Compound Library;Anti-Cancer Compound Library;

Related Small Molecules:RIPA-56;RIPK3-IN-2;GSK2983559 free acid;AV123;RIPK1-IN-8;RIP2 kinase inhibitor 2;RIP2 Kinase Inhibitor 4;PK68;GSK-872;RIPK-IN-4;TP-030-2;OD36;TP-030-1;RIPK2-IN-2;GSK3145095;Necrostatin 2;RIPK1-IN-4;RIPK1-IN-15;GSK-843;(Rac)-GSK547;RIPK2-IN-1;RIP2 kinase inhibitor 1;Kongensin A;PROTAC RIPK degrader-6;RIPK1-IN-10

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