For research use only. We do not sell to patients.
HOIPIN-8
Biological Activity：HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC.
Research Area：Inflammation/Immunology
Targets：E1/E2/E3 Enzyme
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;NF-κB Signaling Compound Library;Oxygen Sensing Compound Library;Ubiquitination Compound Library;Pyroptosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:UBE2T/FANCL-IN-1;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;MD-224;DI-1859;MX69;RG7112;Teslexivir;TRAF6 peptide;AM-8735;NAcM-OPT;RO-5963;SENP1-IN-3;Avadomide;M435-1279;MI-1061;HB007;Ubiquitination-IN-1;Milademetan;EN219;Nutlin-3;NSC624206;Hydrocotarnine;TAK-243;PYR-41;SZL P1-41;Siremadlin;BRD5529;SMIP004
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Structurally and synthetically diverse biologically active compounds；
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