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Apricitabine
CAS No. : 160707-69-7
Biological Activity：Apricitabine (SPD754; AVX754), the (-) enantiomer of 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC), is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor (Ki=0.08 μM), as well as inhibits DNA polymerases α, β, and γ with Ki value of 300 μM, 12 μM, and 112.25 μM, respectively. Apricitabine (SPD754; AVX754) shows promising antiretroviral efficacy, good tolerability and a low propensity for resistance selection in antiretroviral-naive HIV infection[2].
Research Area：Infection
Targets：Nucleoside Antimetabolite/Analog|DNA/RNA Synthesis|HIV
Related Small Molecules:m7GpppCpG;Ametantrone;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;HIV-1 TAT (48-60);Seletracetam lithium;HIV-IN-2;Triptonine B;P1788;FC131;Peritassine A;m7GpppUmpG;Thymidine-13C5,15N;NSC 617145;116-9e;DNA Gyrase-IN-5;DMT-2′-F-Bz-dA;6-Thio-2′-Deoxyguanosine;Flavopiridol
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