For research use only. We do not sell to patients.
Pyr6
CAS No. : 245747-08-4
Biological Activity：Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).
IC50 value: 0.49 uM [1]
Target: TRPC3 inhibitor
Pyr6 is a selective SOCE inhibitor (Yonetoku et al., 2008; Sweeney et al., 2009), Pyr6 displayed 37-fold (1.58 OM) higher potency for RBL SOCE than for TRPC3 ROCE, with an IC50 comparable to that of Pyr2 and Pyr3. Pyr6 at 3 uM diminished TRPC3 currents to only 52%. Consistent with inhibition of Orai channel activity Pyr2, Pyr3 or Pyr6 substantially inhibited typical Orai downstream signalling events in RBL mast cells (NFAT activation and degranulation) activated by passive store depletion.
Research Area：Others
Targets：TRP Channel
Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Mechanoreceptors Compound Library;
Related Small Molecules:V116517;GSK2332255B;Pregnenolone monosulfate sodium;TRPC5-IN-4;OptoBI-1;SB-705498;TRPC3/6-IN-1;ABT-239;Pyr3;Asivatrep;Ononetin;TRPM8 antagonist 3;FEMA 4809;Hydroxy-α-sanshool;GsMTx4 TFA;TRPM4-IN-1;Palvanil;Pregnenolone monosulfate sodium-13C2,d2;Capsazepine;MSP-3;TRPM4-IN-2;Pregnenolone-d4-1;Umbellulone;Icilin;DS88790512;TRPV antagonist 1;ML-SA1
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
About Us:
- MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
- Structurally and synthetically diverse biologically active compounds；
- roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
- We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
- Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；
- Customized order volume ranging from milligrams to kilograms scale；
Structurally and synthetically diverse biologically active compounds；
We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.
