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Shikonin
CAS No. : 517-89-5
Biological Activity：Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor[2] and can also inhibit TNF-α and NF-κB pathway[3]. Shikonin decreases exosome secretion through the inhibition of glycolysis[4]. Shikonin inhibits AIM2 inflammasome activation[7].
Research Area：Cancer
Targets：TNF Receptor|Chloride Channel|NF-κB|Pyruvate Kinase|HIV
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Membrane Transporter/Ion Channel Compound Library;Metabolism/Protease Compound Library;NF-κB Signaling Compound Library;Stem Cell Signaling Compound Library;Natural Product Library;Anti-Cancer Compound Library;Antiviral Compound Library;Anti-Aging Compound Library;Antioxidant Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Medicine Food Homology Compound Library;Glycolysis Compound Library;Pyroptosis Compound Library;Traditional Chinese Medicine Active Compound Library;Exosomes Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Glucose Metabolism Compound Library;Anti-Liver Cancer Compound Library ;Anti-Cancer Natural Product Library;Antidepressant Compound Library;Antiviral Traditional Chinese Medicine Active Compound Library;Anti-inflammatory Traditional Chinese Medicine Active Compound Library;Plant-Sourced Natural Product Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Akt/NF-κB/JNK-IN-1;AX-024;Icariside F2;HIV-1 TAT (48-60);IKKγ NBD Inhibitory Peptide TFA;Seletracetam lithium;HIV-IN-2;Mangiferin;Antioxidant agent-5;ALPK1-IN-1;Triptonine B;Regaloside A;FC131;IMD-ferulic;SN52;Peritassine A;5-Aminosalicylic Acid-D3 hydrochloride;Ginsenoside Rg1;Echinulin;Licochalcone D;TEPP-46;QNZ;Flavopiridol
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