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PD-161570
CAS No. : 192705-80-9
Biological Activity：PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively[2]. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor[3].
Research Area：Cancer|Cardiovascular Disease
Targets：EGFR|Src|FGFR|TGF-β Receptor|PDGFR
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;TGF-beta/Smad Compound Library;Anti-Cancer Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Anti-Cardiovascular Disease Compound Library;Anti-Hepatitis C Virus Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Osteogenesis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:KB SRC 4;Tirbanibulin dihydrochloride;NSC81111;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;ML347;Bafetinib;Osimertinib-13C,d3;p60c-src substrate II;Henatinib;EGFR-IN-5;FGFR2-IN-3;Flumatinib mesylate;IHMT-TRK-284;Caffeic acid-pYEEIE TFA;LDN193189 (GMP);TGFβRI-IN-4;Ferulic acid-13C3;PDGFRα/FLT3-ITD-IN-2;Genistein;Epertinib hydrochloride;PP2;ALK5-IN-6;TGFβ-IN-1;FGFR-IN-7
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