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E3330
CAS No. : 136164-66-4
Biological Activity：E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer activities[2][3][4][5].
Research Area：Cancer|Neurological Disease|Cardiovascular Disease
Targets：AP-1|NF-κB|DNA/RNA Synthesis|Reactive Oxygen Species|VEGFR|HIF/HIF Prolyl-Hydroxylase
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Metabolism/Protease Compound Library;NF-κB Signaling Compound Library;Protein Tyrosine Kinase Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Antioxidant Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Anti-Cardiovascular Disease Compound Library; Ferroptosis Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;Neuroprotective Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Mitochondria-Targeted Compound Library;Transcription Factor-Targeted Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:D-α-Hydroxyglutaric acid disodium;(Z)-FeCP-oxindole;Akt/NF-κB/JNK-IN-1;Chitoheptaose heptahydrochloride;Icariside F2;Ametantrone;N-Acetyl-D-cysteine;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;VEGFR-2-IN-24;IKKγ NBD Inhibitory Peptide TFA;TC-S 7009;BMS-690514;Topoisomerase I/II inhibitor 3;CYPMPO;Mangiferin;Antioxidant agent-5;PROTAC VEGFR-2 degrader-2;ALPK1-IN-1;Regaloside A;Henatinib;P1788;IMD-ferulic;SN52;ROS-ERS inducer 1;Glucosamine-13C hydrochloride
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