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PS10
CAS No. : 1564265-82-2
Biological Activity：PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM). PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy[2].PDK: pyruvate dehydrogenase kinase
Research Area：Inflammation/Immunology
Targets：PDHK
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Metabolism/Protease Compound Library;Anti-diabetic Compound Library;Glycolysis Compound Library;Anti-Cancer Metabolism Compound Library;Mitochondria-Targeted Compound Library;Glucose Metabolism Compound Library;Targeted Diversity Library;
Related Small Molecules:AZD7545;M77976;PDK4-IN-1;PDHK-IN-5;KPLH1130;Dicoumarol-d8;Sodium dichloroacetate;Leelamine;PDHK-IN-3;TM-1;VER-246608;PDHK-IN-4;JX06;Dicoumarol
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