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Filibuvir
CAS No. : 877130-28-4
Biological Activity：Filibuvir is an orally active, selective non-nucleoside inhibitor of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase (RdRp). Filibuvir binds noncovalently in the thumb II allosteric pocket of NS5B. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM for both isoforms, respectively. Filibuvir preferentially inhibits elongative RNA synthesis and potently decreases viral RNA accumulation[2].
Research Area：Infection
Targets：HCV|DNA/RNA Synthesis
Related Small Molecules:Ametantrone;HCV-IN-30;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;HCV-IN-38;P1788;Thymidine-13C5,15N;NSC 617145;116-9e;Sennidin A;DNA Gyrase-IN-5;DMT-2′-F-Bz-dA;HCV-IN-31;6-Thio-2′-Deoxyguanosine;Radalbuvir;Antitumor agent-74;Grazoprevir potassium salt;Risdiplam;FGI-106 tetrahydrochloride;TH287 hydrochloride;BMS-986144;Oenothein B
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