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ML281
CAS No. : 1404437-62-2
Biological Activity：ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA.
target: STK33
IC50: 14 nM [1]
ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]
Research Area：Cancer
Related Screening Libraries:Bioactive Compound Library Plus;Anti-Cancer Compound Library;Targeted Diversity Library;
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