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Trimetrexate

CAS No. : 52128-35-5

Biological Activity：Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC₅₀ values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer^[2][3][4][5].

Research Area：Infection|Cancer

Targets：Parasite|DNA/RNA Synthesis|Antifolate|Bacterial|Antibiotic|Dihydrofolate reductase (DHFR)

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Cell Cycle/DNA Damage Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Antiviral Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Antibacterial Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Antibiotics Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Pancreatic Cancer Compound Library;Antiparasitic Compound library;Anti-Cancer Metabolism Compound Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;

Related Small Molecules:(+)-Isopulegol;Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;Monascorubrin;SR9186;Antileishmanial agent-2;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Leucomycin;Ametantrone;Isouvaretin;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;Antibacterial agent 99;Vidarabine monohydrate;Nafcillin;Antitubercular agent-28;Ochromycinone

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