ADAMTS5 Recombinant Rabbit Monoclonal Antibody [PSH03-52]

Function :
A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene.{{Docetaxel} site|{Docetaxel} Cell Cycle/DNA Damage|{Docetaxel} Biological Activity|{Docetaxel} Data Sheet|{Docetaxel} supplier|{Docetaxel} Autophagy} ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.{{D(+)-Galactosamine} site|{D(+)-Galactosamine} Biological Activity|{D(+)-Galactosamine} In Vivo|{D(+)-Galactosamine} custom synthesis|{D(+)-Galactosamine} Cancer} Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif.PMID:35116795 Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. ADAMTS5 may also have a role in the pathogenesis of human osteoarthritis.