CD32B Mouse Monoclonal Antibody [A9C11]

Product Name :
CD32B Mouse Monoclonal Antibody [A9C11]

Predicted band size :
34 kDa

Observed band size :
39 kDa

Synonyms:
CD32 antibody CD32 antigen antibody CD32B antibody CDw32 antibody Fc fragment of IgG, low affinity II, receptor for (CD32) antibody Fc fragment of IgG, low affinity IIb, receptor antibody Fc fragment of IgG, low affinity IIb, receptor (CD32) antibody Fc fragment of IgG, low affinity IIb, receptor for (CD32) antibody Fc fragment of IgG, low affinity IIb, receptor for antibody Fc gamma receptor IIB antibody 展开

Function :
Fc fragment of IgG receptor IIb (coded by FCGR2B gene) is a low affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG). FCGR2B participates in the phagocytosis of immune complexes and in the regulation of antibody production by B lymphocytes. The receptor inhibits the functions of activating FcγRs, such as phagocytosis and pro-inflammatory cytokine release, mainly by clustering of FCGR2B with different activating FCGR receptors or with the BCR by immune complexes. The phosphorylated ITIM of FcγRIIB recruits the inositol phosphatases SHIP1 and SHIP2, which inhibit the Ras activation, downregulate MAPK activity and reduce PLCγ function and lead to decreased activation of PKC. Inhibition of the MAP kinase pathway, together with the anti-apoptotic kinase Akt can negatively affect proliferation and survival of the cells.Estramustine phosphate sodium FCGR2B regulates B cell activation by increasing the BCR activation threshold and suppressing B cell mediated antigen presentation to T cells through the ITIM-dependent inhibitory mechanism. Ligation of FCGR2B on B cells downregulates antibody production, prevents the membrane organization of BCR and CD19 and promotes apoptosis. Co-ligation of FCGR2B on dendritic cells inhibits maturation and blocks cell activation. .The negative regulatory role of the FCGRIIB molecule is not limited to BCR-induced B-cell activation, but is also functional on other B-cell activation pathways mediated by CD40 and IL-4. FCGR2B expression on follicular dendritic cells (FDCs) is important for capturing the antigen-containing immune complexes which are essential for the germinal centre response. FCGR2B is present on non-leukocyte cells including airway smooth muscle and liver sinusoidal endothelial cells, where small immune complexes are internalized inhibiting the pro-inflammatory signalling.

Antibody Type:
Mouse Monoclonal Antibody

Immunogen :
Recombinant protein within human aa 1-250 / 310.

Species reactivity:
Human

Verify application:
WB, IHC-P

Coupling :
unconjugated

Clone number:
A9C11

RRID:
AB_3071843

Form :
Liquid

Concentration :
1ug/ul

Storage instructions:
Store at +4℃ after thawing.Gastrodin Aliquot store at -20℃.PMID:23075432 Avoid repeated freeze / thaw cycles.

Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Subtype:
IgG1

Purification method :
Protein A affinity purified.

ELTSA :

Molecular weight :
Predicted band size: 34 kDa

Positive control :
Daudi cell lysate, Raji cell lysate, HL-60 cell lysate, human placenta tissue lysate, human tonsil tissue, human liver tissue, human colon carcinoma tissue, human placenta tissue.

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