THZ-P1-2

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THZ-P1-2

CAS No. : 2058075-45-7

Biological Activity:THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines.

Research Area:Cancer

Targets:Autophagy

Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Anti-Cancer Compound Library;Autophagy Compound Library;Covalent Screening Library;Anti-Blood Cancer Compound Library;Targeted Diversity Library;

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