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CAS No. : 1361414-26-7

Biological Activity:SR9186 (ML368) is a potent CYP3A4 inhibitor with IC50 s for inhibition of midazolam → 1′hydroxymidazolam, testosterone → 6β-hydroxytestosterone, and vincristine → vincristine M1 of 9, 4, and 38 nM, respectively. SR-9186 inhibits liver-stage development of P. falciparum to block ivermectin metabolism.

Research Area:Infection

Targets:Parasite|Cytochrome P450

Related Screening Libraries:Bioactive Compound Library Plus;

Related Small Molecules:(+)-Isopulegol;Antileishmanial agent-2;Azlocillin sodium salt;AMG-208;SQ109;Trypanothione synthetase-IN-3;CYP1B1-IN-1;CYP2C9/CYP2C19-IN-1;Pyrantel;α-Terpinene;Dehydrocorydaline;Hypericin;Niclosamide monohydrate;Febrifugine dihydrochloride;Antimalarial agent 15;Cycloguanil hydrochloride;Anti-infective agent 6;Morantel tartrate

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