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CAS No. : 1898206-17-1

Biological Activity:Safusidenib is an orally bioavailable, selective mutant IDH1 inhibitor. Safusidenib strongly inhibits mutant IDH1 but not wild-type IDH1. Safusidenib impairs tumor activity in chondrosarcoma. Safusidenib exhibits activity against IDH1R132H, and IDH1R132C with IC50s of 15, and 130 nM in assays without any preincubation, respectively[2].

Research Area:Cancer

Targets:Isocitrate Dehydrogenase (IDH)

Related Small Molecules:mIDH1-IN-1;Enasidenib mesylate;AGI-12026;IDH1 Inhibitor 2;DS-1001b;BAY-1436032;Mutant IDH1-IN-1;(R,S)-Ivosidenib;AGI-5198;IDH-C227;IDH1 Inhibitor 1;AGI-6780;Mutant IDH1-IN-6;Olutasidenib;IDH-305;IDH1 Inhibitor 3;IDH2R140Q-IN-1;Vorasidenib;(S,R)-GSK321;IDH889;IDH1 Inhibitor 5;Mutant IDH1 inhibitor;Mutant IDH1-IN-2;Mutant IDH1-IN-4;GSK864

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