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RU-SKI 43
CAS No. : 1043797-53-0
Biological Activity:RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity.
Research Area:Cancer
Targets:Hedgehog
Related Small Molecules:Dynarrestin;RL-0070933;SANT 2;Ciliobrevin D;TPB15;CUR61414;HSP70-IN-3;SANT-1;Hh-Ag1.5;SMANT hydrochloride;Robotnikinin;Ciliobrevin A;SMO-IN-2;RUSKI-201 dihydrochloride;JK184;MK-4101;3-epi-Vitamin D3;Neurodazine;TAK-441;Jervine;SMO-IN-3
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